Throughout most of their lives, women are at a greater risk of becoming depressed than men. Some evidence suggests that this heightened risk is associated with increased sensitivity to the hormonal changes that occur across the female reproductive lifecycle.
A number of biological and environmental factors are independent predictors for depression in this population, including the presence of hot flashes, sleep disturbance, history of severe premenstrual syndrome or postpartum blues, ethnicity, history of stressful live events, past history of depression, body mass index and socioeconomic status.
This paper explores the current knowledge on the complex associations between mood changes and aging in women. More specifically, the biological aspects of reproductive aging and their impact on mood, psychosocial factors, lifestyle, and overall health are reviewed. In addition, evidence-based hormonal and non-hormonal therapies for the management of depression and other complaints in midlife women are discussed.
Ultimately, this article should help clinicians Depression 50 year old woman health professionals "Depression 50 year old woman" address a challenging clinical scenario: Depression in mid-life women is a significant cause of morbidity and disability 1.
The unique manifestations and multifactorial etiology of mid-life depression makes it difficult to recognize and treat 2. In addition, symptoms of depression may overlap with those associated with menopause, presenting a clinical dilemma for psychiatrists and other health professionals in women's health 3.
As the baby-boomer generation of women approaches and passes menopause, midlife depression has become a serious public health issue and the subject of interest of a growing number of epidemiological and clinical studies. This paper examines the evidence for and the nature of relationships between mood symptoms and aging in women, including chronological and reproductive aging, and between mood symptoms and other psychosocial, lifestyle, and health factors.
In addition, the biological basis for development of depressive symptoms in mid-life women, and the potential for hormonal and non-hormonal therapies to provide relief, are discussed. Mid-life women may seek medical advice due to Depression 50 year old woman symptoms as hot flashes, aches and stiff joints, trouble sleeping, and lack of energy.
Of particular interest, nervous tension and feelings of downheartedness and sadness were among the six most common complaints. The causal relationships between depressive symptoms and menopause, however, are unclear; a particular controversy has been established around the question whether depressed mood is caused by psychological factors related to aging or whether ovarian hormonal changes may play a significant role in its occurrence.
Research on the relationship between menopause and depressive symptoms has provided contradictory results. Several studies revealed no relationship 5 - 7while others found that mood symptoms decreased with increasing age or that there was an increase in depression among women in "Depression 50 year old woman" menopausal transition 9. Controlling for the presence of vasomotor symptoms reduced the correlations between depression and menopause in some reports A strong relationship was found between hysterectomy and depressed mood Longitudinal studies that followed subjects through the transition from regular menstruation to the post-menopausal period have provided contradictory results as well.
Different methodologies and the confounding effect of chronological aging make the results of "Depression 50 year old woman" studies difficult to compare. In addition, correlations "Depression 50 year old woman" changes in ovarian hormones and mood are not clear, because few studies measured "Depression 50 year old woman" parameters. Some longitudinal studies have shown no relationship between depression and menopause 10 Other studies demonstrated an increased risk of depression during the transitional phase from peri-menopause to post-menopause 1314 ; in particular, women entering this transitional phase earlier had a significant risk of developing new-onset depression Dennerstein et al 12 found both an improvement in mood during mid-life and a decrease in negative mood as menopausal symptoms improved.
A recent restaging study 17 has used data to provide clinicians with practical definitions of the stages of the menopausal Irregular menses, defined as more than 7 days difference persistently occurring between the length of cycles, is characteristic of the early menopausal transition, which begins at about age The late menopausal transition begins when there have been at least two missed menstrual periods, and the post-menopause is the period which begins after the last menstrual period.
The Melbourne Women's Mid-Life Health Project study showed that estradiol levels varied widely early in the menopausal transition, with a dramatic decrease in the late menopausal transition period, while follicle-stimulating hormone FSH increased After the final menstrual period, estradiol levels continued to Depression 50 year old woman and FSH continued to rise.
The occurrence of physical and Depression 50 year old woman symptoms in women during menopausal Depression 50 year old woman stages was documented in the Women's International Study Depression 50 year old woman Health and Sexuality WISHeSa large cross-sectional survey of women aged 20 to 70 years in France, Germany, Italy, the United Kingdom, and the United States. Subgroups of women at several stages were prospectively defined, and symptoms in physical, vasomotor, psychosocial and sexual domains were evaluated Regularly menstruating women aged 20 to 49 were compared with post-menopausal women aged 50 to 70 and also with women who had surgical menopause before and after age Subjects with surgical menopause were of interest because oophorectomy removes approximately half of circulating androgens, as well as estradiol, and the effects are more severe and sudden than naturally occurring menopause These symptoms reached a maximum prevalence at age 50 and earlier in women who had early before age 50 surgical menopause.
There was a curvilinear effect of age, and there were no differences between women from different countries and no effect of body mass index on the prevalence of this group of symptoms In contrast, psychological symptoms, such as Depression 50 year old woman swings, and breast pain showed a curvilinear pattern that peaked much earlier at age 35 to 40 years, or during the early menopausal transition period.
After age 35 to 40 years, mood symptoms decreased with age through menopause and into the post-menopausal period and were increased in the presence of other physical or mental health problems.
Interestingly, significant differences were found between women from different countries in the prevalence of this group of symptoms A third cluster of symptoms was also observed that did exhibit a linear effect of age with no maximum prevalence at age These symptoms, such as decreasing physical strength and lack of Depression 50 year old woman, are the expected effects of increasing age and were also affected by the country of origin, body mass index, and other physical and mental problems Similar results were found in the Melbourne Women's Mid-Life Health Project, in which positive and negative moods, as well as hormone levels, were followed in a longitudinal fashion.
Depressed mood declined significantly with aging. The results also showed that being in the menopausal transition phase amplified the negative mood effects of other major life events, such as poor health or job loss This vulnerability period is similar in nature to other well-known vulnerability phases, such as the premenstrual period and the immediate post-partum period.
The Melbourne Women's Mid-Life Health Project investigators found several risk factors associated with depression during the menopausal transition. A previous history of depression or premenstrual tension, negative attitudes about menopause, as well as lifestyle and psychosocial Depression 50 year old woman, were important risk factors for depressive symptoms In addition, a follow-up study 11 years later of women aged 57 to 67 found that depression was highest for those who had surgical menopause and for those who were still menstruating In another substudy, happiness scores during and after the menopausal transition were followed and found to be significantly related to happiness scores recorded before the transition began.
Before and after the menopausal transition, happiness scores were the effect of intrinsic personality factors and extrinsic factors, such as marital status, work satisfaction, and life events In general, well-being increased over time as women passed through the menopausal transition, and no direct effect of levels could be ascertained Interestingly, the return of children to home during the menopausal transition resulted in reductions of positive mood and decline in the frequency of sexual activity for Depression 50 year old woman The consequences of physical, emotional, or sexual violence on mood in mid-life women were also evaluated.
This substudy of the Melbourne Women's Mid-Life Health Project showed that intimate partner violence predicted depressed mood, divorce or separation, low sexual functioning, and use of psychotropic drugs Psychotropic drug use was associated with interpersonal stress, poor self-ratings of health, and premenstrual depression Structural equation modeling has been used to show the relationships between changing estradiol levels and the symptoms specifically associated with declining estradiol levels.
Women's sleep and perception of health Depression 50 year old woman affected by vasomotor symptoms. Poor lifestyle choices, daily hassles, and stressors also affect mood. Also, decreases in estradiol compromise mood by affecting sexual functioning and women's feelings for partners Chaotic changes in hormone levels during the menopausal transition may be one of the major factors in increased risk of depression 27 - An ongoing longitudinal study, the Harvard Study of Moods and Cycles, reported on the long-term, prospective evaluation of women who were pre-menopausal 36 to 44 years of age at the time of enrollment.
They received periodic hormonal, psychiatric, and quality of life assessments, and the results were controlled for factors that are commonly investigated in depression, such as body mass index, smoking, marital status, and occupational status. The data from this study indicate that peri-menopausal women were two times more likely than premenstrual women to develop new-onset severe depression.
In addition, the risk was exacerbated in those who Depression 50 year old woman vasomotor symptoms during peri-menopause This study indicates that peri-menopause and vasomotor symptoms, caused by estrogen fluctuations, may Depression 50 year old woman a common biochemical pathway with depressive symptoms. The history of estrogen research provides ample evidence to support a strong role for estrogen in regulating brain function. Depression 50 year old woman effects and a role in preserving memory and cognition are well documented, as are thermoregulatory and antidepressant effects in animal and clinical studies.
The brain regions most likely to be affected by estrogen are those more likely to be related to monoaminergic systems, including the serotonergic and norepinephrine systems 31and other evidence supports the role of estrogens in synthesis, release, and receptor activity of Depression 50 year old woman and norepinephrine 32 Consequently, it is intuitive to believe that the absence or intense fluctuation of estrogen could result in mood and behavioral changes, as well as vasomotor and other menopausal symptoms.
Several controlled clinical studies examined whether estrogen therapy may have an antidepressant effect in peri-menopausal and post-menopausal women with major depressive disorder 3034 - An important finding of these studies was that estrogen was not efficacious for depression in post-menopausal women, suggesting that fluctuating estrogen levels, rather than absolute estrogen levels, may be more important for the antidepressant effects of estrogen.
Another interesting aspect of these studies was that positive results were associated with use of transdermal rather than oral estrogen. This finding may be due to the heightened bioavailability of estradiol with transdermal administration, which could be advantageous for the interaction with estrogen receptors in brain areas "Depression 50 year old woman" regulate mood and behavior.
Another point for consideration in treatment of depression in mid-life women is the efficacy of antidepressant therapies for relief of physical symptoms of menopause, such as hot flashes.
A set of prescription data collected by McIntyre et al 38before and after publication of negative results concerning the use of hormone replacement therapy from the Women's Health Initiative in July 39may be relevant to this question.
The initial reports of the Women's Health Initiative study suggested no protective effect against actually, a slightly increased risk for cardiovascular events e. As a result, physicians became more reluctant in prescribing estrogen, even for younger, symptomatic Depression 50 year old woman. The study by McIntyre et al 38 demonstrated that hormone replacement therapy prescriptions decreased in the year following the Women's Health Initiative results; interestingly, the number of prescriptions for antidepressants significantly increased, suggesting either that women developed psychological symptoms Depression 50 year old woman. Limited comparisons of estrogen and antidepressant therapies for treatment of depression in women with menopausal symptoms have indicated similar efficacy of escitalopram 40 and hormone therapies for relief of menopausal symptoms and improvement in menopause-related quality of life measures.
Duloxetine 41 and citalopram 42 open trials also suggest that antidepressants may have a positive impact on menopausal symptoms, an important treatment consideration for women who cannot or will not take estrogen. Other point of interest is whether age Depression 50 year old woman menopausal status of mid-life women
Depression 50 year old woman affect the efficacy of some antidepressant therapies. Several clinical trials have shown differences between the responses to antidepressants of pre- vs.
In a pooled analysis, responses to selective serotonin reuptake inhibitors SSRIs appear to be affected by age i. The question of whether estrogen plays a role in this Depression 50 year old woman in efficacy was investigated in a pooled analysis of data from women over 50 years of age who were or were not receiving concomitant estrogen therapy during treatment with SSRIs or venla-faxine in eight studies.
This study showed higher response rates to venlafaxine than SSRIs in both groups. However, the gap in efficacy between SSRIs and venlafaxine was significantly larger in women who did not receive estrogen therapy, and SSRIs were significantly more effective than placebo only in the women who received estrogen The emergence of vasomotor symptoms in mid-life women is hypothesized to be the result of disturbed thermoregulatory function, a complex, hypothalamus-based process.
As estrogen levels fluctuate, the so-called thermoneutral zone becomes significantly narrowed, leading to frequent sweating or shivering in response to normal changes in body temperature and producing the characteristic heat dissipation of menopause Although estrogen remains the gold standard for treatment of vasomotor symptoms, several alternative therapies, including many natural remedies, have been investigated.
These include psychoactive medications, such as antidepressants, "Depression 50 year old woman" stabilizers, anticonvulsant medications, and anti-anxiety therapies 51 - It should be pointed out that two of the most popular natural remedies for vasomotor symptoms, soy and black cohosh, have been found to have very little impact on these symptoms when compared with placebo in controlled trials 59 and that women may still be exposed to adverse events and side effects through their use.
Another strategy for women with significant nocturnal vasomotor symptoms night sweats would be to improve sleep patterns.
A trial of the sleep agent eszopiclone for menopausal women with insomnia and awakenings due to hot flashes was recently shown to have a positive effect on these symptoms. The treatment also promoted improvement of mood and
Depression 50 year old woman of life, possibly due to improved sleep patterns Epidemiological and clinical studies demonstrate that mood changes and depressive symptoms may occur in some women during the menopausal transition.
Estrogen fluctuations may affect mood changes indirectly, through mediation of menopause-related physical symptoms, particularly sleep and sexual disturbances. In addition, estrogen may affect both vasomotor and depressive disturbances through common biochemical pathways and receptor-mediated actions on brain function.
Estrogen therapy has Depression 50 year old woman shown to improve both mood and vasomotor symptoms and remains a viable option for symptomatic mid-life women. older man resting chin in hands Actually, there are more than 50 different symptoms of major depression, ranging from the well-known—crying and sadness—to Women are about twice as likely as men to be diagnosed with depression.
Here are 13 possible midlife crisis warning signs for women that may anywhere between their 40s and early 50s — something that's been.
Depression 50 year old woman if I would call it clinical depression, but there is a If you consider yourself to be older than your years (or refer to yourself as being an "old lady" or. Signs of Depression in Women – Symptoms in Girls, Mature Women, Geriatric Women Fortunately, in recent years mental illness has become a more open topic of.
The signs of depression in women over 50 and well into their 90s is of a.
Why won't he just commit?Sufferers from depression, we are told, are too ashamed or The heroines of chick lit are 10 years older than the heroines of Jane Austen. Depression is nearly twice as likely to affect women than men Symptoms can last weeks, months, or years and can be intermittent or a . Unfortunately, depression in women can have misdiagnosis rates as high as 50%..
Very, there are more than 50 incommensurable symptoms of significant pit, ranging from the well-known—crying and sadness—to those you superiority not at any time associate with gloom, such as infuriate, workaholism and struggling against odds injure.
Masses who are depressed are low more no doubt to sire other long-standing medical conditions, including cardiovascular condition, repudiate worriments, arthritis, diabetes, and huge blood load, and to sooner a be wearing worse outcomes.
Cavity is not exactly debilitating; it can be barbarous. An estimated entire at liberty of five inhabitants with glumness pass on have suicide at some mark. Downturn is not a spirit you can virtuous climb over and beyond. It is a illness in which the intellectual ceases to list pleasurable activities, says Angelino. Of course, MRI studies with depressed citizens bear ground changes in the parts of the intellect that make believe a meritorious duty in dimple.
As women, we have divers life roles. Mother, old lady, employee, friend, healer, caregiver, and the list goes on. The complexity of all of these roles can cause ups and downs throughout life. Some of these mood changes may be due to life events e. That can be a debilitating cycle and can manifest itself due to a figure of causes.
Symptoms can last weeks, months, or years and can be intermittent or a one-time occurrence. Depression is barely twice as likely to affect women than men and tends to enjoy different contributing causes in women than it does in men. Listed inferior are the different forms of depression most cheap in women.
Every six months, I go to the psychiatrist. Would I always be experimenting with combinations and new drugs to figure out how to feel better? I may never get off depression medication, but that's OK.
It turns out that this is only kind of true. Elizabeth Trattner, anxiety and depression do rise in women as they age, particularly between the ages of 35 and 50 when it peaks. What these three depressions have in common is the increasing and decreasing of hormones, specifically estrogen, which plays a significant role in regulating brain function. Doctors run into the wall of having to make sure that any antianxiety medication an individual is prescribed does not have an adverse drug interaction with any other medication they may be taking — in some cases, limiting medication options.
- For some women, the peri-menopause and early post-menopausal years may . in women younger than 50 years of age than in women older than 50 years). Learn more from WebMD about how depression in women is treated during various mature couple riding bicycles Here are the facts about depression in women: In the U.S., about 15 million people experience depression each year. . Menopause typically occurs in a woman's late 40s to early 50s.
- D epression is in the news these days.
- The unique challenges of managing depression in mid-life women
- Sufferers from depression, we are told, are too ashamed or The heroines of chick lit are 10 years older than the heroines of Jane Austen. Depression is nearly twice as likely to affect women than men Symptoms can last weeks, months, or years and can be intermittent or a . Unfortunately, depression in women can have misdiagnosis rates as high as 50%.
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Depression in Women
The most benefits for depression come from rhythmic exercise—such as walking, weight training, swimming, martial arts, or dancing—where you move both your arms and legs. Their hormones change rapidly during these years, together with the physical changes in their bodies as they are readied for womanhood and their child-bearing years.
These fall into four classes: Make face-time a priority. Consequently, it is intuitive to believe that the absence or intense fluctuation of estrogen could result in mood and behavioral changes, as well as vasomotor and other menopausal symptoms.
depression symptoms in women over 50
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